Solvent dependent 4-aminosalicylic acid-sulfamethazine co-crystal polymorph control

Para-Aminosalicylic Acid: Pas

Crystal structure of [Co(NH3)6][Co(CO)4]2

Hexaamminecobalt(II) bis-[tetra-carbonyl-cobaltate(-I)], [Co(NH3)6][Co(CO)4]2, was synthesized by reaction of liquid ammonia with Co2(CO)8. The Co(II) atom is coordinated by six ammine ligands. The resulting polyhedron, the hexa-amminecobalt(II) cation, exhibits point group symmetry -3. The Co(-I) atom is coordinated by four carbonyl ligands, leading to a tetra-carbonyl-cobaltate(-I) anion in t...

Synthesis of a novel PEGylated colon-specific azo-based 4- aminosalicylic acid prodrug

Objective(s): 4-aminosalicylic acid (4-ASA) is an isomer of mesalazine that has recently been shown to be effective against inflammatory bowel disease (IBD), and more specifically, ulcerative colitis. However, the majority of orally administered 4-ASA is readily and extensively absorbed from the stomach and small intestine, so only a small amount is transported to the ...

Crystal structure of (E)-N′-(4-chloro­benzyl­idene)-4-methyl­benzene­sulfono­hydrazide: a hexa­gonal polymorph

The title compound, C14H13ClN2O2S, crystallized in the enanti-omorphic defining hexa-gonal space group P61 [Flack parameter = -0.02 (7)]. The partially hydrated form of the same compound, crystallizing in the triclinic space group P-1, has been reported previously [Kia et al. (2009b). Acta Cryst. E65, o1119], as has the crystal structure of the bromo derivative, also crystallizing in the space ...

aminosalicylic acid to 5-aminosalicylic acid in topical treatment of ulcerative colitis. Digestion